YY1

Represor transcripcional YY1
	; Estructura tridimensional de la proteína YY1.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1UBD , 1ZNM
Identificadores
Símbolos	YY1 (HGNC: 12856) DELTA; NF-E1; UCRBP; YIN-YANG-1
Identificadores; externos	OMIM: 600013 ; HomoloGene: 2556 ; EBI: YY1; GeneCards: Gen YY1; UniProt: YY1;
Locus	Cr. 14 q32.2
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
7528	22632
Véase HS	Véase MM
P25490	Q00899
NM_003403	NM_009537
NP_003394	NP_033563
Cr. 14:; 100.7 – 100.75 Mb	Cr. 12:; 108.79 – 108.82 Mb
;

El represor transcripcional YY1 (YY1) es una proteína codificada en humanos por el gen YY1.[1][2]

YY1 es un factor de transcripción distribuido ubícuamente, perteneciente a la clase GLI-Kruppel de proteínas con dedos de zinc. Es una proteína implicada en la represión y activación de diversos promotores. YY1 puede dirigir las histona deacetilasas y las histona acetiltransferasas hacia los promotores, además de activar o reprimir el promotor en cuestión, por lo que presenta un papel relevante en la modificación de histonas.[3]

Interacciones

La proteína YY1 ha demostrado ser capaz de interaccionar con:

Referencias

Shi Y, Seto E, Chang LS, Shenk T (Nov de 1991). «Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein». Cell 67 (2): 377-88. PMID 1655281.
Zhu W, Lossie AC, Camper SA, Gumucio DL (Jul de 1994). «Chromosomal localization of the transcription factor YY1 in the mouse and human». Mamm Genome 5 (4): 234-6. PMID 7912122.
«Entrez Gene: YY1 YY1 transcription factor».
Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (Oct. de 1997). «Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family». J. Biol. Chem. (UNITED STATES) 272 (44): 28001-7. ISSN 0021-9258. PMID 9346952.
Yao, Y L; Yang W M, Seto E (Sep. de 2001). «Regulation of transcription factor YY1 by acetylation and deacetylation». Mol. Cell. Biol. (United States) 21 (17): 5979-91. ISSN 0270-7306. PMID 11486036.
Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (Feb. de 1997). «Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1». Nucleic Acids Res. (ENGLAND) 25 (4): 843-9. ISSN 0305-1048. PMID 9016636.
Yang, W M; Yao Y L, Seto E (Sep. de 2001). «The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1». EMBO J. (England) 20 (17): 4814-25. ISSN 0261-4189. PMID 11532945. doi:10.1093/emboj/20.17.4814.
Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (Jul. de 2000). «ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1». Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096-106. ISSN 0270-7306. PMID 10866666.
Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. de 1993). «Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc». Science (UNITED STATES) 262 (5141): 1889-92. ISSN 0036-8075. PMID 8266081.
Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (Jun. de 2003). «Modulation of YY1 activity by SAP30». Biochem. Biophys. Res. Commun. (United States) 306 (1): 267-75. ISSN 0006-291X. PMID 12788099.
Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (mayo. de 1995). «Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300». Genes Dev. (UNITED STATES) 9 (10): 1188-98. ISSN 0890-9369. PMID 7758944.
Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (Oct. de 2003). «Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch». J. Biol. Chem. (United States) 278 (43): 41963-9. ISSN 0021-9258. PMID 12913000. doi:10.1074/jbc.M304353200.
García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun. de 1999). «RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1». EMBO J. (ENGLAND) 18 (12): 3404-18. ISSN 0261-4189. PMID 10369680. doi:10.1093/emboj/18.12.3404.

Datos: Q18032405

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[pmid1655281-1] Shi Y, Seto E, Chang LS, Shenk T (Nov de 1991). «Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein». Cell 67 (2): 377-88. PMID 1655281.

[pmid7912122-2] Zhu W, Lossie AC, Camper SA, Gumucio DL (Jul de 1994). «Chromosomal localization of the transcription factor YY1 in the mouse and human». Mamm Genome 5 (4): 234-6. PMID 7912122.

[3] «Entrez Gene: YY1 YY1 transcription factor».

[pmid9346952-4] Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (Oct. de 1997). «Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family». J. Biol. Chem. (UNITED STATES) 272 (44): 28001-7. ISSN 0021-9258. PMID 9346952.

[pmid11486036-5] Yao, Y L; Yang W M, Seto E (Sep. de 2001). «Regulation of transcription factor YY1 by acetylation and deacetylation». Mol. Cell. Biol. (United States) 21 (17): 5979-91. ISSN 0270-7306. PMID 11486036.

[pmid9016636-6] Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (Feb. de 1997). «Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1». Nucleic Acids Res. (ENGLAND) 25 (4): 843-9. ISSN 0305-1048. PMID 9016636.

[pmid11532945-7] Yang, W M; Yao Y L, Seto E (Sep. de 2001). «The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1». EMBO J. (England) 20 (17): 4814-25. ISSN 0261-4189. PMID 11532945. doi:10.1093/emboj/20.17.4814.

[pmid10866666-8] Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (Jul. de 2000). «ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1». Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096-106. ISSN 0270-7306. PMID 10866666.

[pmid8266081-9] Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. de 1993). «Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc». Science (UNITED STATES) 262 (5141): 1889-92. ISSN 0036-8075. PMID 8266081.

[pmid12788099-10] Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (Jun. de 2003). «Modulation of YY1 activity by SAP30». Biochem. Biophys. Res. Commun. (United States) 306 (1): 267-75. ISSN 0006-291X. PMID 12788099.

[pmid7758944-11] Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (mayo. de 1995). «Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300». Genes Dev. (UNITED STATES) 9 (10): 1188-98. ISSN 0890-9369. PMID 7758944.

[pmid12913000-12] Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (Oct. de 2003). «Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch». J. Biol. Chem. (United States) 278 (43): 41963-9. ISSN 0021-9258. PMID 12913000. doi:10.1074/jbc.M304353200.

[pmid10369680-13] García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun. de 1999). «RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1». EMBO J. (ENGLAND) 18 (12): 3404-18. ISSN 0261-4189. PMID 10369680. doi:10.1093/emboj/18.12.3404.